Something rotten is brewing beneath the industrial mecca known as Raccoon City. Unknown to it's millions of residents, a huge underground bioengineering facility known as The Hive has accidentally unleashed the deadly and mutating T-virus, killing all of it's employees. To contain the leak, the governing supercomputer, Red Queen, has sealed all entrances and exits. Now a team of highly-trained super commandos including Rain (Michelle Rodriguez), Alice (Milla Jovovich) and Matt (Eric Mabius) must race to penetrate The Hive in order to isolate the T-virus before it overwhelms humanity. To do so, they must get past the Red Queen's deadly defences, face the flesh-eating undead employees, fight killer mutant dogs and battle The Licker, a genetically mutated savage beast whose strength increases with each of it's slain victims.